Contrave: Naltrexone/Bupropion ER

Contrave is an FDA-approved weight-loss medication that combines two medicines, naltrexone and bupropion, to target areas of the brain involved in appetite, cravings, and energy balance. Together, they help reduce persistent hunger and food-related urges, while supporting metabolic pathways that influence how the body uses energy. Patients often experience fewer cravings for highly rewarding foods and more control over eating habits throughout the day. Contrave is used as part of a structured treatment program that includes nutrition support, movement plans, and regular follow-up visits through tele-medicine to help patients build sustainable lifestyle habits.

This medication works differently from stimulant-based treatments and may be an option for individuals who prefer a non-stimulant approach or who have struggled with emotional eating, cravings, or late-day hunger. During the tele-medicine evaluation, the medical provider reviews the patient’s history, current medications, and mood symptoms to decide whether Contrave is appropriate. Because the medication contains bupropion, mood history is reviewed thoughtfully, and patients receive education on what to expect during treatment. Ongoing appointments allow the provider to adjust the plan, monitor tolerance, and reinforce strategies that support long-term weight control.

Contrave is not suitable for everyone. It should not be used during pregnancy and is avoided in people with uncontrolled high blood pressure, a history of seizures, bulimia, or anorexia. It is also not used in individuals who are stopping alcohol or certain medications abruptly, or who have severe kidney disease. Because naltrexone blocks opioids, anyone currently taking opioid medications for pain must avoid Contrave and allow an appropriate time interval before starting therapy. Some medications can interfere with how Contrave works, including other forms of naltrexone or bupropion, certain HIV medicines, seizure medications, and monoamine oxidase inhibitors. These considerations are reviewed carefully during the tele-medicine appointment.

At Cornerstone Health MD, the use of Contrave is integrated into a broader virtual weight-care plan. Patients receive guidance on nutrition patterns that support appetite control, strategies for managing cravings, and tools for tracking daily progress. Treatment focuses on long-term habit change rather than quick losses, and medication is used only when it fits the patient’s medical profile and goals. The tele-medicine format allows patients to receive care from home while staying connected to a clinical team, making the process flexible and accessible while maintaining medical oversight.